What is it?
Etrust AV - isafe.exe

What does it do?
isafe.exe is a part of Etrust AV which is also use by Zone Labs Internet Security. You should not end this process for any reason. This handles the scanning of emails for viruses and possibly some automatic updates.

Virus Precautions:
You'll want to keep an eye on this google search for any known viruses. The normal location of this file is C:WINDOWSsystem32oneLabsisafe.exe OR C:PROGRAM FILESCAETRUST EZ ARMORETRUST EZ ANTIVIRUSISAFE.EXE